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| Catalog No?： | IPB0004 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | IHC-p; ELISA |
| Dilution： | IHC: 1:50-1:200 ELISA: 1:10000 |
| Gene Name： | IL1A |
| Protein Name： | Interleukin-1 alpha |
| Human Gene Id： | 3552 |
| Swiss-Prot： | P01583 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cytoplasm Secreted The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059) |
| MW： | 30607 |
| Background： | The protein encoded by this gene is a member of the interleukin 1 cytokine family This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8618805223559
bio100plus@126.com
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