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EnglishCatalog No?: | IPB0010 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; ELISA |
Dilution: | WB: 1:500-1:2000 IHC-p: 1:100-1:200 ELISA: 1:20000 |
Gene Name: | CD1E |
Protein Name: | T-cell surface glycoprotein CD1e membrane-associated |
Human Gene Id: | 913 |
Swiss-Prot: | P15812 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | [T-cell surface glycoprotein CD1e, membrane-associated]: Golgi apparatus membrane; Single-pass type I membrane protein Early endosome Late endosome Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells [T-cell surface glycoprotein CD1e, soluble]: Lysosome lumen |
MW: | 35986 |
Background: | This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members |
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